Brighton welcome back Leandro Trossard after a brief illness saw him miss the midweek trip to Manchester City.
Steven Alzate has recovered from a virus and could be involved while Yves Bissouma serves the final game of a two-match suspension.
Southampton appear to have no new injury concerns after their defeat to Burnley on Thursday.
Goalkeeper Alex McCarthy is nearing full fitness after nearly five months out with a hamstring injury.
LAWRO'S PREDICTION
Southampton have had the upper hand in this south-coast battle in recent years - Brighton won at St Mary's Stadium last season, but that is their only win in their nine Premier League meetings since 2017.