Brentford hope to welcome back captain Pontus Jansson following his ongoing struggles with a hamstring injury.
Southampton defender Kyle Walker-Peters is out after pulling his hamstring during the midweek defeat by Newcastle.
Moussa Djenepo is pushing for a recall after a spell out with concussion, while new signings Kamaldeen Sulemana and Paul Onuachu are available.
CHRIS SUTTON'S PREDICTION
Southampton have improved a lot recently and gave Newcastle a decent game in the Carabao Cup in midweek, but they have now lost three out of their past four games in all competitions.