Bournemouth striker Callum Wilson has been cleared of concussion after sustaining a head injury against Leicester on Tuesday.
However, Ryan Fraser is having scans on an ankle injury and is unlikely to be involved against Southampton.
Saints midfielder Oriol Romeu will miss his first league game of the season because of suspension.
Defender Cedric Soares is doubtful with the illness which has ruled him out of the last two matches.
WHAT THE MANAGERS SAY
Bournemouth manager Eddie Howe: "The motivation for us is to try to keep moving up the league.
"The challenge for me is to improve the team and I have made that very clear all year, our target was to improve on last season.