Arsenal manager Mikel Arteta is uncertain whether Oleksandr Zinchenko, who is nursing a groin issue, will be available for Friday's match.
William Saliba remains sidelined by a back injury which Arteta admits is taking longer to heal than anticipated.
Takehiro Tomiyasu and Mohamed Elneny are long-term absentees.
Southampton's Ainsley Maitland-Niles is ineligible against his parent club but Mislav Orsic is back in contention after overcoming a hip problem.
Che Adams, Mohammed Salisu and Juan Larios are still injured, while this game may come too soon for Tino Livramento.
MATCH FACTS
Head-to-head
- Arsenal are unbeaten in 27 top-flight home matches against Southampton (W19, D8), one shy of their longest run against a particular opponent (ongoing versus Fulham since 1949).