Barcelona manager Xavi Hernandez could opt to rest Ronald Araujo and Ilkay Gundogan for Sunday’s clash with Athletic.
The duo are facing a long flight back from international duty and will not return to training until Friday.
Araujo has been with Uruguay and was part of the team that inflicted a 2-0 defeat on the Selecao in World Cup qualifying.
Meanwhile, Gundogan has been in the United States for friendlies with Germany against the USMNT and Mexico.
Sport are reporting that there are doubts over both players who have both played 180 minutes over the international break.