Watford versus Manchester United sees an injury-hit Red Devils squad travel down to Vicarage Road for the teams' first meeting since April 2007, per 11v11.com.
The last time United lost this fixture was in September of 1986 when a 1-0 Watford win came as part of a run of games that would eventually lead to Ron Atkinson being replaced by the then-Aberdeen manager Alex Ferguson.
Each of the nine meetings between the two sides in league and cup since then have resulted in United victories.
For Saturday's clash to repeat the historical precedent, United will need to find goals from somewhere.