Ryan Giggs leads his country out as manager for the first time in a competitive game as the Dragons host Martin O'Neill's Boys in Green
Wales and the Republic of Ireland kick off their UEFA Nations League campaign on Thursday when they face off at Cardiff City Stadium.
The neighbouring countries have become familiar foes in recent years, coming up against each other as recently as the World Cup 2018 qualification phase.
During that campaign, they played out a tempestuous 0-0 draw in Dublin before Ireland emerged victorious in Cardiff, where a James McClean goal gave Martin O'Neill's side a crucial 1-0 win.