The Azzurri are seeking to bounce back after failing to qualify to the Nations League finals when they meet the Americans in Belgium
The U.S. national team will complete its 2018 calendar with a friendly international against Italy in Genk, Belgium.
Neither team has had a successful year, having been high-profile absentees from the World Cup in Russia, while serious strides have yet to be made about restoring their respective reputations in the game.
The USMNT were outclassed 3-0 by England at Wembley on Thursday, while the Azzurri missed out on the playoff stages of the Nations League following a scoreless draw with Portugal on Saturday.