Tottenham Hotspur will look to tighten their grip on second against Europa League-chasing Southampton, before Manchester City host Arsenal with a place in the Champions League at stake. Liverpool also take on Watford.
Meanwhile, it's the penultimate day of the season in La Liga, with Barcelona, Atletico Madrid and Real Madrid all battling for top spot.
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13.20 BST: Elsewhere in the world, Barca host Espanyol, Atletico travel to face Levante and Real welcome Valencia at 16.00 BST. We've also got Manchester City vs.