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Real Madrid opened up a three-point lead at the top of La Liga after they won 1-0 at Real Valladolid on Sunday.
Barcelona were beaten 2-0 by Valencia at the Mestalla Stadium, while Atletico Madrid slipped down to fifth after a 0-0 draw at home to Leganes.
Sevilla, meanwhile, moved up to third with their 2-0 victory over Granada.
Here are the results from Week 21 in La Liga, and the updated standings:
LaLiga @LaLigaENMatchday 21. u2705 Which result surprised you the most?