Tottenham Hotspur will look to tighten their grip on second against Europa League-chasing Southampton, before Manchester City host Arsenal with a place in the Champions League at stake. Liverpool also take on Watford.
Meanwhile, it's the penultimate day of the season in La Liga, with Barcelona, Atletico Madrid and Real Madrid all battling for top spot.
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15.27 BST: Spurs clearly deflated from missing out on the title and that showed in their performance. Lamela and the two fullbacks -- Walker and Rose -- the three stand-out stars for Pochettino's side in what was a fairly lacklustre performance.