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Real Madrid hit back from a goal down to win 3-2 at Sporting Gijon on Saturday as Isco finished off a heroic brace in the 90th minute to move Los Blancos six points clear at La Liga's summit.
The midfielder first responded to Duje Cop's 14th-minute breakthrough before adding his second in the game's dying minutes, with Alvaro Morata cancelling out Mikel Vesga's headed effort earlier in the second half.
Real manager Zinedine Zidane handed league starts to Morata, Lucas Vazquez and Marco Asensio, with Nacho and Sergio Ramos the only surviving starters from Wednesday's 2-1 UEFA Champions League victory over Bayern Munich.