Andres Iniesta, Thiago Alcantara and Dani Carvajal have been dropped to the bench for Spain's World Cup knock-out clash with Russia.
Marco Asensio, Koke and Nacho have been drafted into the starting XI in what is likely to be merely a technical decision.
Iniesta's exclusion comes as something of a shock, but the former Barcelona icon's form against Morocco wasn't that of his usual dominating self.
Nacho, meanwhile, replaces Real Madrid team-mate Carvajal at right-back, with the latter also having had a sub-par performance against the Atlas Lions.
For Russia's part, the hosts look to be setting up a 3-4-3 against La Furia Roja, which signals the first time they have deviated from their 4-2-3-1 since the start of the tournament.