Spain became the first visiting team come from behind and beat England in a competitive match at Wembley Stadium for 67 years with their 2-1 Nations League victory on Saturday.
Goals from Saul Niguez and Rodrigo secured a win for Luis Enrique's side in his first game in charge of La Roja after he saw them fall behind early to a Marcus Rashford goal.
Only once before have England gone ahead in a competitive fixturee at the national stadium and gone onto lose - their 3-2 defeat to Scotland in the 1951 Home Nations tournament.
It is also only the 10th occasion in which England have scored at Wembley in competitve football and still fallen to defeat.