Tottenham Hotspur will look to tighten their grip on second against Europa League-chasing Southampton, before Manchester City host Arsenal with a place in the Champions League at stake. Liverpool also take on Watford.
Meanwhile, it's the penultimate day of the season in La Liga, with Barcelona, Atletico Madrid and Real Madrid all battling for top spot.
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20': Freekick to Southampton after Rose is penalised for fouling in the away side's half. Mane looks to take quickly, but's it's over-hit out for a throw in.