Lee Grant, Ethan Laird, Di'Shon Bernard and Dylan Levitt will all be granted full senior debuts for Manchester United against Astana, Ole Gunnar Solskjaer has confirmed.
The Red Devils have already booked their place in the Europa League knockout stages after picking up three wins and a draw from their opening four fixtures, to sit top of Group L ahead of AZ.
Solskjaer has the opportunity to rest key personnel when his side travel to Kazakhstan to face Astana, who have yet to pick up a single point in the competition this season.