Santiago Solari refused to respond to Isco's claims about a lack of opportunities at Real Madrid, but did hint the Spain midfielder needs to work harder in training.
Isco has struggled for playing time this season, making just five league starts in Madrid's 22 La Liga games this term, with his opportunities becoming even sparser in recent weeks.
Former Madrid midfielder Ruben de la Red warned the Spain playmaker that "Madrid don't wait for anyone" on Thursday, prompting Isco to respond on Twitter: "I agree with De la Red but when you do not enjoy the same opportunities as your team-mates, things change.