The Bundesliga side had a string of chances to prevail in the Champions League clash, but Javier Hernandez was among those guilty of missing the target
Roger Schmidt could not hide his irritation at Bayer Leverkusen's failure to beat BATE Borisov on Tuesday.
A shocking error from goalkeeper Bernd Leno allowed Mikhail Gordeichuk to open the scoring with the host's first attack of the match.
Javier Hernandez missed a great opportunity to equalize on the stroke of halftime as his run of scoring in seven consecutive matches came to an end in Belarus.