Tottenham Hotspur will look to tighten their grip on second against Europa League-chasing Southampton, before Manchester City host Arsenal with a place in the Champions League at stake. Liverpool also take on Watford.
Meanwhile, it's the penultimate day of the season in La Liga, with Barcelona, Atletico Madrid and Real Madrid all battling for top spot.
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68': ARSENAL GOAL! Game of brilliant individual goals! Sanchez does so well after picking up the ball in the middle of the pitch, lays it off to Giroud for a quick one-two and then slots it side footed into the net.