The Dutchman had the chance to equalise against Tony Pulis' side, but goalkeeper Boaz Myhill dived low to his left to palm it away as United went on to record their third league defeat in a row.
Asked if Van Persie would continue as United's No. 1 penalty-taker, manager Louis van Gaal stated that he would not, per BBC Sport: "No. He is now at the end of the road. It is always [the same]. Wayne Rooney has missed also, so when you miss, you are at the bottom again."
Van Persie's start against West Brom was his first since February, and he was arguably lacking sharpness, though Myhill's save was still impressive, per the Express and Star's Steve Madeley:
Not a great penalty by Van Persie but a very good save by Myhill.