The final match of Wednesday's six-game slate in the Copa del Rey pits Rayo Vallecano against Atletico Madrid at the Estadio de Vallecas at 4:05 p.m. ET/9:05 p.m. GMT.
Diego Simeone's men enter the round-of-16 contest in first place in the league table and off a 1-0 home win over Levante on Saturday.
A victory on the road in the first of two legs against Rayo Vallecano would hand Atleti a nice advantage heading into next week's second leg in Madrid.
Rayo Vallecano will be looking to avenge a defeat at home to Atleti on December 30 in league play.