Ernesto Valverde was the Barcelona manager known for embarrassing defeats in the UEFA Champions League, but he was ultimately sacked not for one particular match, but for a series of them.
The old coach was ultimately let go when he went five matches with only one win. Extenuating circumstances (one was against Real Madrid, another was a loss to Atlético in which Barcelona played well, one was Real Sociedad at Anoeta, and one was a derby against Espanyol) be damned.
This is, ultimately, how we we got to Quique Setién.