Jurgen Locadia and Luuk De Jong were the saviors for the Dutch team, which gave its chances of making the knockout stages a huge boost with three points.
PSV has left a fierce race for qualification to the next round of the Champions League, after gaining a vital 2-0 win over Wolfsburg in Eindhoven.
The Dutch team leapfrogged Wednesday's opponent behind Manchester United, taking the second spot in Group B by virtue of better results between the teams.
Jurgen Locadia and Luuk De Jong both struck in the second half to secure a priceless victory for PSV, with two games remaining in the group phase.