Arsenal face their last chance to prove they are still in the Premier League title race when they make the daunting trip to Everton to face a side suddenly in buoyant mood under manager Roberto Martinez.
Nothing less than three points will do for embattled Arsenal chief Arsene Wenger. One more defeat will knock his fragile team out of the race and expose the Frenchman to unprecedented levels of criticism that could spark the bitter end of his otherwise illustrious tenure.
A split may be coming much sooner for Manchester United and Louis van Gaal. Knocked out of the UEFA Europa League by Liverpool and sixth in the league table, Van Gaal will know how much losing the Manchester derby would further sour the mood in the red half of the city.