Premier League leaders Manchester City host 2015-16 champions Leicester City at the Etihad Stadium in Week 27.
The pair will contest Saturday's evening clash, after Arsenal and Tottenham Hotspur kick off proceedings at lunchtime with the north London derby.
Liverpool travel to Southampton on Sunday afternoon, while earlier in the day Newcastle United will host Manchester United at St James' Park.
Here is the full schedule, including viewing information and score predictions for each:
Saturday, Feb. 10
12:30 p.m. GMT/7:30 a.m. ET: Tottenham Hotspur vs. Arsenal (BT Sport, CNBC), 2-2
3 p.