Jose Mourinho will return to Old Trafford with Tottenham Hotspur on Wednesday just under a year on from his sacking as Manchester United boss.
Manchester City desperately need three points at Burnley on Tuesday after their 2-2 draw against Newcastle United on Saturday saw them drop 11 points behind leaders Liverpool, who host Everton in the Merseyside derby in Week 15.
Meanwhile, Chelsea are at home to Aston Villa, and Arsenal play Brighton & Hove Albion as they attempt to end their eight-game winless run in all competitions.
Week 15 Fixtures and Predictions
Tuesday, December 3
Crystal Palace 2-1 Bournemouth: 7:30 p.