Jose Mourinho's first Premier League game in charge of Manchester United and Pep Guardiola's debut in England's top flight with Manchester City are the highlights of the first slate of games for the new season.
Both are intense rivals and have each spent big this summer overhauling squads that are now expected to be serious title contenders.
Speaking of the title, champions Leicester City may have been weakened by the loss of midfield destroyer N'Golo Kante, but they've retained striker Jamie Vardy and made some smart new signings. They should still be favourites for a tricky trip to newly promoted Hull City.