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Watford beat Liverpool 3-0 on Saturday to inflict a first Premier League defeat of the season on Jurgen Klopp's side.
The Reds went into the game chasing a record-breaking 19th consecutive league win but were deservedly beaten by the struggling Hornets at Vicarage Road.
Elsewhere, Marcos Alonso hit a double for Chelsea as the Blues were forced to come from behind to secure a 2-2 draw with Bournemouth at the Vitality Stadium.
Saturday also saw wins for Crystal Palace and West Ham United, while Newcastle United were held to a goalless draw by Burnley.