Sides such as Manchester United, Chelsea and Arsenal will not have their fixture lists altered to accommodate their participation in European competition.
The Premier League will not reschedule games for clubs competing in the Champions League, according to chief executive Richard Scudamore.
In some European leagues, clubs involved in either the Champions League or Europa League can have domestic fixtures pushed forward or back to accommodate their extra exertions in midweek.
But the Premier League has generally avoided providing similar relief and will continue to do so, Scudamore has confirmed.
While England's UEFA coefficient - the ranking that determines how many spots each league receives in both European club competitions - has declined, dropping them below Germany into third, Scudamore believes the logistics involved in rescheduling matches is too difficult to implement.