Chelsea welcome Arsenal to Stamford Bridge on Saturday in the standout Premier League fixture in Week 2.
New Arsenal manager Unai Emery will be hoping to pick up his first points since taking charge of the Gunners. His team were beaten 2-0 at home by Manchester City on the opening weekend.
The match is not the only London derby on Saturday, as Tottenham Hotspur take on newly promoted Fulham at Wembley Stadium.
Sunday also brings some intriguing fixtures. Reigning champions Manchester City face Huddersfield Town, while Manchester United travel to Brighton & Hove Albion.
The Week 2 action concludes on Monday night when Jurgen Klopp's Liverpool head to Selhurst Park to play Crystal Palace.