Manchester City's hopes of retaining the Premier League title are fading, and the champions host Manchester United on Saturday.
Liverpool have become increasingly stronger at the top of the league, with the Reds travelling to Bournemouth on the same day as the Manchester derby.
Jose Mourinho's Tottenham Hotspur will attempt to get back to winning ways when they welcome Burnley after Wednesday's 2-1 defeat at Old Trafford.
Elsewhere, Chelsea travel to Everton, with the Toffees searching for a new coach after sacking Marco Silva, and Arsenal visit West Ham United on Monday.
Leicester City remain Liverpool's nearest Premier League challengers, with the Foxes featuring on Sunday at Aston Villa.