Maurico Pochettino hopes for "understanding" from England over Harry Kane's involvement in the upcoming international break.
Kane has only scored in one of his last five appearances for Spurs and was substituted in the 77th minute of Sunday's 1-0 win over Crystal Palace at Wembley, having taken a heavy knock to the ankle in the first half.
England face friendly matches against Brazil and Germany over the next fortnight, with Tottenham's Dele Alli having already pulled out of the squad due to injury.
A third Spurs player, Harry Winks, suffered an injury at Wembley on Saturday, but Pochettino will not withdraw anyone who is fit to travel, although offered a thinly veiled suggestion for Gareth Southgate to manage his players' workload.