Rachid Alioui's effort was not enough as Nicolas Pepe and Jonathan Bamba led Lille to a 3-2 victory over Nimes on Sunday.
The visitors started well with Rafael Leao's opener in the fourth minute but were reduced to 10 men after Jose Fonte's expulsion in the 16th minute.
Despite the setback, Bamba doubled his side's lead just four minutes before half-time.
The Ivorian increased his tally to eight goals for the Great Danes as he continues his impressive form this season.
After the restart, Bamba set Pepe up for Lille's third goal in the 66th minute.