The Dutch coach, who won four Eredivisie titles with Ajax, has signed a three-year contract with the Serie A side after Roberto Mancini's departure.
Frank de Boer has been appointed as the new head coach of Inter on a three-year deal, the club has announced.
Inter has acted swiftly to replace Roberto Mancini, who left his role at San Siro on Monday amid reports of a dispute with Suning Holdings Group, the club's new owners.
De Boer quickly emerged as the favourite to take the reins and the former Ajax boss's arrival has now been confirmed.