A Naby Laye Keita penalty secured Asante a 1-0 victory over Inter Allies in the Ghana Premier League on Wednesday.
The Guinean's 68th-minute effort, after Kwame Opoku was fouled in the box, proved the decisive factor in the match week 12 fixture at the Accra Sports Stadium.
The Porcupine Warriors are third on the league table, one point behind Karela United and Great Olympics, who are tied on 21 points at the top of the standings.
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Elsewhere on Wednesday, Bechem United's hopes of possibly jumping to the top of the table were dashed by a 2-0 away loss to Berekum Chelsea, who scored through Collins Ameyaw and Kofi Owusu.