Jose Mourinho will name a strong Tottenham team at Shkendija on Thursday, rather than calling on the players who were set to face Leyton Orient.
The compact nature of the new season has provided Spurs with a frantic fixture list, with three matches scheduled for this week.
However, Tuesday's Carabao Cup meeting with Orient was called off after the League Two club announced a number of positive coronavirus tests in their first team.
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Mourinho had previously professed his frustration at the Carabao Cup schedule and also bemoaned a "world of contradictions" after West Ham played Hull City despite their own Covid-19 cases.