Mexico is traveling to Queretaro to face Chile in front of a sold-out crowd at the Estadio Corregidora.
El Tri notched a 3-2 win over Costa Rica last week, their first victory since the World Cup.
While Pachuca midfielder Victor Guzman was among the stars in that match, the second game of the friendly window will see PSV winger Hirving Lozano, Wolves forward Raul Jimenez and other Europe-based stars play a bigger role than they did against the Ticos.
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Chile, meanwhile, is coming off a 3-0 defeat to Peru but a reinforcement is arriving that coach Reinaldo Rueda hopes can give his team a competitive edge.