The Argentine starts for the first time since suffering his knee injury on Sept. 26, while Luis Enrique makes two other changes to the side that beat Real Madrid on Saturday.
Lionel Messi has made the starting lineup for Barcelona's Champions League clash with Roma.
The Argentine came on as a second-half substitute in Saturday's 4-0 win over Real Madrid but has not started a game since he suffered a knee injury in the 2-1 victory against Las Palmas on Sept. 26.
Luis Enrique makes two other changes from the side that embarrassed Rafa Benitez's men in the Clasico.