Ernesto Valverde feels Lionel Messi's injury provides an opportunity for Barcelona players to step up, although he acknowledges the team will miss their captain.
Messi has been ruled out for three weeks after sustaining a fractured arm in a heavy fall during Saturday's 4-2 La Liga win at home to Sevilla.
The Argentina attacker will therefore be unavailable to face Inter in the Champions League on Wednesday, as well as missing next weekend's Clasico.
Barca have not won a Clasico without Messi since he made his debut for the club in 2004 and they failed to beat Athletic Bilbao when he was rested last month.