Juventus forward Mario Mandzukic has been ruled out of his side's Champions League group stage match against Manchester United on Tuesday.
The Croatian star will miss the clash as the result of an injury to his left ankle, per Goal, while Sami Khedira will also be absent for the trip.
Mandzukic has registered four goals and two assists in his 10 appearances for Juve so far this season and his presence up front will be sorely missed.
While Massimiliano Allegri will have limited options in attack due to this development, the manager will be happy to have Cristiano Ronaldo available as the Portuguese faced the threat of suspension for the upcoming match after getting sent off against Valencia in Juve's first group stage encounter.