Marcus Rashford will be assessed on the day of the game to establish if he can play a part in the Europa League clash against Granada on Thursday.
The forward limped off in the win against Brighton at the weekend but trained with his team-mates on Wednesday morning ahead of flying out to Spain. The England international could be fit to start but it is unlikely he will last the full first leg of the quarter-final clash.
Ole Gunnar Solskjaer has promoted 18-year-old winger Anthony Elanga to the first-team squad in the absence of Anthony Martial, who is missing with a knee injury he picked up on international duty.