Portugal can confirm qualification to UEFA Euro 2020 if they beat Luxembourg on Sunday.
The defending champions will finish second in Group B with victory but will also progress if third-placed Serbia fail to beat group winners Ukraine in their final game.
Luxembourg head into the match on a run of six straight defeats, including a 3-0 loss in Portugal when the two sides last met in October.
Date: Sunday, 17 November
Time: 2 p.m. GMT/9 a.m. ET
TV:Sky Sports Football (UK), TUDN USA (U.S.)
Live Stream:Sky Go (UK)
Odds (courtesy of Oddschecker):Luxembourg 28-1, Draw 17-2, Portugal 1-12
Match Preview
Cristiano Ronaldo heads into the match after scoring his ninth international hat-trick in a 6-0 win over Lithuania on Thursday:
Squawka FootballCristiano Ronaldo has now scored his ninth hat-trick for Portugal.