The midfielder's effort in the first half opened the scoring Lusitanians were made to work by their hosts, before a rather fortuitous free kick put the game beyond doubt.
Andre Andre's first-half goal and a late Nani free kick sealed a narrow 2-0 friendly win for Portugal in Luxembourg, although the hosts had plenty of chances to pull off a shock result.
Andre's strike, a low shot converting Vieirinha's cross, opened the scoring on the half-hour mark, with Lucas Joao guilty of missing two brilliant opportunities to extend the lead.
Luxembourg was full of confidence after pulling off a surprise 1-0 victory against Greece on Friday and battled hard, Stefano Bensi and Aurelien Joachim both going close.