Exorcising the frustration of respective opening-game setbacks will be high on the agenda for Lyon and Valencia.
Lyon and Valencia endured frustrating opening games in Champions League Group H and will seek to kick-start their qualification bids at Stade de Gerland on Tuesday.
Hubert Fournier's men were held 1-1 by a Gent side which had two players sent off - with Alexandre Lacazette missing a late penalty - while the Liga outfit suffered a 3-2 home loss to Zenit.
Valencia will hope to draw some inspiration from the previous group-stage showdowns between the two sides, when the Spaniards prevailed in both matches back in 2000-01.