The Barcelona converted past the Verde to reach a half-century with the national team, as he keeps up the chase on top-scorer Gabriel Batistuta.
Lionel Messi has reached 50 international goals after the Argentina star scored against Bolivia in Tuesday's World Cup qualifier.
The Barcelona superstar was on target with a penalty to put the Albiceleste 2-0 up against the Andean nation, with 28 minutes played of the first half.
His first goal in international colors came on March 1, 2006, in a friendly against Croatia at the age of 18. That same year, Messi went on to become Argentina's youngest-ever scorer in a World Cup finals when he scored in a 6-0 rout of Serbia.