Barcelona are seeking to win the Copa del Rey for a record 31st occasion and will face Levante in the round of 16, with the first leg to be played at Estadi Ciutat de Valencia on Thursday.
The Catalans made a winning start to 2019, beating Getafe 2-1 last Sunday thanks to goals from Lionel Messi and Luis Suarez, carrying them five points ahead of second-placed Atletico Madrid in La Liga.
Levante, meanwhile, find themselves 10th in the Primera Division but are only six points clear of the drop zone in what is a fiercely congested league.