Tottenham defender Kieran Trippier will be available for Mauricio Pochettino against Southampton after recovering from an injury which has kept him out of action in recent weeks.
However, several others players will be absent through injury or suspension, including long-term absentees Mousa Dembélé, Erik Lamela, and Davinson Sanchez.
There are now five Tottenham players set to miss out on midweek action the Premier League. The worry for Spurs is that those missing out will be leaving big gaps in a side that is already lacking defensive cover and options in midfield.
TEAM NEWS: @ErikLamela (thigh) – undergoing rehabilitation for a minor muscle injury@daosanchez26 (hamstring) – continues to progress with on-field rehabilitation@VictorWanyama (knee) – continuing treatment and rehabilitation@JanVertonghen - serving one-game suspension pic.