Juventus midfielder Sami Khedira has had another injury setback after spraining an ankle in training, with the Italian club confirming he is a "big doubt" to face SPAL.
Khedira has missed most of the season so far with thigh injury and has made just one Serie A appearance since the middle of September.
He did, however, start against Manchester United in the Champions League earlier this month and was introduced as a late substitute in the recent 2-0 victory against AC Milan.
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The German international could now miss Juve's home game against SPAL on November 24, and may also be absent for the Champions League visit of Valencia three days later.