Los Blancos will be without the Colombian playmaker for the trip to Celta Vigo, with Marcelo, Luka Modric, Dani Carvajal and Pepe also out
James Rodriguez has suffered another calf injury setback as Real Madrid head coach Zinedine Zidane counts the cost of mounting fitness problems for the La Liga leaders.
Colombia playmaker James has missed Madrid's last four matches in all competitions due to an injury to his left calf and has now damaged the same muscle in his right leg, with local media reports predicting a further two to three weeks on the sidelines.
"James has a problem with his other leg," Zidane said ahead of Wednesday's Copa del Rey trip to Celta Vigo, where Madrid will seek to overturn a 2-1 deficit from the first leg of the quarter-final.