Ingolstadt's maiden top-flight outing on home soil ended in defeat as Matthias Ginter opened his Borussia Dortmund account.
Borussia Dortmund spoiled Ingolstadt's first Bundesliga match at the Audi-Sportpark as Thomas Tuchel's men ran out 4-0 winners.
The home side weathered a first-half storm, but could not deny Dortmund after the interval as Matthias Ginter scored his first goal for the club and Marco Reus converted a penalty, before late strikes from Shinji Kagawa and Pierre-Emerick Aubameyang added gloss.
Ingolstadt – seeking to build on its opening-day win over Mainz – did show promise, though, and forced Roman Burki into some excellent saves.